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Denver Broncos 21–17 Philadelphia Eagles

Denver's quarterback found a short scoring throw and the running back contributed another rushing score in the fourth quarter as the Broncos overcame a 14-point deficit to deliver the Eagles their initial defeat of the season. Denver's defense deflected the Eagles quarterback's last-gasp attempt on the contest's last snap to hand the reigning title holders to just their second defeat in their previous 22 outings. The Broncos (3-2) caught a huge break in their rally when the Eagles had a crucial play called back on an illegal shift penalty whistled against running back Saquon Barkley.

Texans Dominate Depleted Ravens in Record Win

CJ Stroud passed for 244 passing yards and four touchdowns, and Houston (2-3) strolled to a 44-10 win over an injury-ravaged Ravens squad, matching both the most lopsided road win in Texans' history and the most lopsided home loss in Ravens' history. Baltimore (one win and four losses) were missing two-time MVP quarterback Lamar Jackson, and that was not their sole issue. Defensive standouts multiple defensive leaders all missed the game, and the Baltimore already were depleted on that side of the ball because of a cervical issue that concluded Nnamdi Madubuike's season. The Ravens were also missing All-Pro fullback Patrick Ricard and offensive lineman Stanley.

Colts Rout Raiders in One-Sided Affair

Indianapolis' running back ran for three rushing scores and a two-pointer, and Daniel Jones threw two scoring throws as the Colts routed the Raiders. This decisive advantage was Indy's largest since the 2013 season. The quarterback completed 20 of 29 for 212 passing yards and moved to 4-1 as the starting quarterback this year, surpassing his total wins over the past two seasons with the Giants. Taylor carried 17 times for 66 yards and caught three receptions for 20 receiving yards. The Colts converted multiple takeaways into touchdowns. Las Vegas fell to four wins and one loss.

Dallas Cowboys 37-22 New York Jets

Dallas' quarterback passed for four touchdown passes, guiding the Dallas Cowboys to a comfortable win over the Jets. Dallas scored on two 90-yard drives in the second period, even with missing key linemen on the offensive line. Javonte Williams gained 135 rushing yards and a score and also hauled in a TD pass. Dallas, now 2-2-1, bounced back from a 40-40 tie against the Packers last week. New York are still without a victory at 0-5 in Aaron Glenn's inaugural year as head coach.

Minnesota Vikings 21–17 Cleveland Browns

Minnesota wideout Addison grabbed a 12-yard scoring reception from the quarterback with under half a minute left to give the Vikings a win over the Cleveland Browns at the UK venue. The 10-play, 80-yard drive gave the Minnesota (three wins and two losses) a crucial victory on their historic international road trip, which began with a 24-21 loss to the Pittsburgh in Ireland last Sunday. It also spoiled the rookie's first NFL start, as the Browns first-year player put his team (1-4) in position to win by throwing two touchdown passes. Another first-year player Judkins rushed for 110 rushing yards on 23 carries. Wentz overcame an arm issue that briefly sent him to the locker room and led two touchdown marches in the latter half.

Miami Dolphins 24-27 Carolina Panthers

Bryce Young passed for two touchdowns and Rico Dowdle ran for 206 rushing yards and a touchdown as the Carolina Panthers came back against the Miami Dolphins in their home stadium. The quarterback's short pass to the first-year receiver with 1:59 to go gave the Carolina (2-3) the decisive advantage as they matched the largest comeback to win a game in team history by erasing a 17-point hole. The QB had a horrific first quarter, but he ended up 19-for-30 passing for 198 yards with an interception. Dowdle, filling in for injured Chuba Hubbard, did his work on the run on 23 attempts, falling just short shy of the single-game franchise rushing record. Miami's quarterback threw 27 passes out of 36 for 256 passing yards with three touchdowns and receiver Waddle accumulated 110 yards through the air on six catches and scored a score, but the Miami (1-4) fell to zero wins and three losses in away contests.

New York Giants 14–26 New Orleans Saints

New Orleans' quarterback threw an 87-yard touchdown to receiver Shaheed, defensive back Howden returned a fumble the length of the field for a touchdown, and the Saints beat the error-prone Giants for the New Orleans' first victory under first-year head coach Moore. Rattler earned his first victory in 11 professional starts, passing for 225 passing yards without a turnover. New York's first-year signal-caller Dart, who secured his debut last Sunday, threw for 202 yards and two scores, but also committed errors on three occasions. New York gave up possession on five separate plays in all, none more costly than when the defender forced a fumble from ball carrier Skattebo, leading to Howden's touchdown. Both teams are 1-4.